Backed by Research. Driven by Results.

Scientific Research

At Spinal Simplicity, we are committed to advancing the field of spine care through rigorous research and evidence-based solutions. Below, you will find peer-reviewed publications, conference abstracts, and other data demonstrating the safety, efficacy, and performance related to our core technologies.

Minuteman® Studies

Minuteman® is a minimally invasive, interspinous-interlaminar fusion device designed to provide stabilization and fusion for patients suffering from segmental degenerative instabilities such as lumbar spinal stenosis and spondylolisthesis.

  1. Posterior Lateral Arthrodesis as a Treatment Option for Lumbar Spinal Stenosis

    • Summary: This study evaluates the effectiveness of the Minuteman® device in providing pain relief and functional improvement in patients with lumbar spinal stenosis.
    • Link: Read Full Study

  2. Instrumented Posterior Arthrodesis of the Lumbar Spine: A Prospective Study

    • Summary: Prospective evaluation of radiographic fusion outcomes in patients receiving instrumented posterior arthrodesis of the lumbar spine using a minimally invasive interspinous fixation device.
    • Link: Read Full Study

  3. 24-Month Outcomes of Indirect Decompression Using a Minimally Invasive Interspinous Fixation Device vs. Standard Open Direct Decompression

    • Summary: An early stage multicenter, prospective randomized control trial with 5-year follow-up to compare the efficacy of a MIS lateral interspinous fusion device (Minuteman) to open direct surgical decompression in lumbar spinal stenosis. Two-year results presented.
    • Link: Read Full Study

  4. Interspinous Interbody Fusion via a Strictly Lateral Surgical Approach

    • Summary: A biomechanical stabilization comparison of interspinous-interbody fusion via a strictly lateral surgical approach versus constructs requiring both lateral and posterior approaches.
    • Link: Read Full Study

  5. Single Position, Single Incision Approach for Lateral Interbody Fusion with Supplemental Posterior Fixation

    • Summary: Compares perioperative, clinical, and radiographic outcomes of lateral lumbar interbody fusion (LLIF) followed by posterior fixation in three patient cohorts treated via different minimally invasive stabilization workflows.
    • Link: White Paper
    • Data presented at 2021 SMISS Annual Forum

  6. Interspinous Fixation as a Treatment for Degenerative Lumbar Disease: A Multi-Center Retrospective Registry Analysis

    • Summary: These registry-based findings support the Minuteman® device as a safe, minimally invasive option for treating degenerative lumbar disease and segmental instability. While the small sample size at longer follow-ups is a limitation, this pilot data shows promising outcomes that may become statistically significant as more data is collected. The device’s low complication rate, minimal blood loss, and efficient surgical profile make it an attractive adjunct or alternative to both conservative and more invasive surgical options. Most notably, the trend toward improved function and patient satisfaction with reduced reliance on narcotics warrants further investigation in prospective studies
    • Link: Download ASPN Abstract
    • Presented at ASPN 2025

Intralink®* Research

IntraLink®* is a novel injectable technology offering biomechanical stability with a minimally disruptive approach, designed to optimize outcomes while reducing procedural complexity. 

  1. Pathomechanics of Early-Stage Lumbar Intervertebral Disc Degradation Leading to Discogenic Pain—A Narrative Review

    • Summary: A review of emerging intradiscal treatment strategies. Understanding the characteristics of progressive tissue degradation, especially the degradation that accumulates prior to the typical onset of pain and disability, is critically important.
    • Link: Read Full Study (Bioengineering Journal, 2024)

  2. A Self-Polymerizing Mesh of Nano-Tethers for the Mechanical Constraint of Degraded Intervertebral Discs—A Review of 25 Years of Pre-Clinical and Early Clinical Research

  3. Early Clinical Results of Intervertebral Joint Stabilization by Injectable Load-Sharing Polymers

    • Summary: Clinically meaningful improvements in pain and disability scores were reported in 80% or more of patients from 2 weeks to 1 year post-treatment. For the more severely unstable joints, treatment significantly reduced the instability score from a pre-treatment level of 2.4 standard deviations above the mean for an asymptomatic population to the asymptomatic mean at the 3-month follow-up.
    • Link: Read Clinical Trial Report (Journal of Pain Research)

 *IntraLink is not FDA cleared and is not available on the market or in any country.

Liberty SI™ Research

The Liberty SI™ Fusion System is intended for sacroiliac (SI) joint fusion for conditions including SI joint disruptions and degenerative sacroiliitis. The procedure involves the lateral insertion of 1 or 2 titanium implants transfixing across the ilium and sacrum, designed to apply a compressive force to stabilize and fuse the SI Joint. Liberty SI™ is single use and provided sterile.

    1. Anatomic Evaluation of Sacroiliac Joint Dimensions: An Imaging Series Study to Define Safety Parameters

      • Summary: An evaluation of SI joints to determine safety zone measurements for the lateral approach to SI joint fusion.
      • Link: Read Full Abstract
    2. Biomechanical Evaluation of a Novel Compressive Lateral Sacroiliac Joint Implant Compared to a Static Lateral Predicate Device 
      • Summary: In an initial review of cadaveric testing comparing to two static implants, the single compressive device demonstrated comparable stabilization in flexion-extension and superior outcomes in axial rotation and joint compression. The compressive implant showed more consistent biomechanical performance across all planes, achieving a superior performance without compromising anatomical safety or requiring excessive bone resection, and compressing the joint more effectively. These early results support the mechanical viability of single-implant lateral fixation approaches. ​
      • Link: Read Full Abstract
      • Presented at ASPN 2025

Patriot SI™ Research

The Patriot SI Implant System is intended for sacroiliac joint fusion for conditions including sacroiliac joint disruptions and degenerative sacroiliitis. The Patriot SI Implant pierces the cortical bone of the ilium and sacrum and is intended to stabilize and fuse the sacroiliac joint. The Patriot SI Implant is placed in-line with the SI joint through a posterior approach, fixating on both the sacrum and ilium.

  1. Worst-Case Biomechanical Assessment of a Posterior Intra-Articular Sacroiliac Joint Implant Compared to a Posterolateral Transfixing Predicate Device

    • Summary: Early study results showed that the intra-articular implant demonstrated similar or superior biomechanical stabilization compared to the posterolateral implant, with statistically significant improvement in flexion-extension stability. The posterior intra-articular approach also provided safer implant positioning and required less bone removal. Unlike the posterolateral implant, the intra-articular implant allows direct access to the articular surfaces for both decortication and preferred graft placement. ​
    • Link: Read Full Abstract 
    • Presented at ASPN 2025
  2. A Novel Posterior Implant System for Sacroiliac Joint Fusion: Preliminary Cadaveric and Clinical Results
    • Summary: A cadaveric biomechanical evaluation was conducted comparing the posterior implant to a posterolateral transiliac implant, evaluating each device’s ability to reduce flexion/extension motion after initial fixation and fatigue loading when used as standalone fixation. Anatomical safety analysis was performed on each implant’s post-fixation position, measuring minimum distances to critical SI landmarks on computed tomography (CT) scans. A retrospective clinical evaluation was also conducted, assessing early patient-reported outcomes for patients treated with the posterior device as standalone.
    • Link: Read Full Study

Stay Informed 

Spinal Simplicity continues to support clinical research, data collection, and innovation to drive the future of minimally invasive spine care. Please check back regularly for new publications and ongoing study updates.